Whistling in the Wind

While Donald Trump is a Queens native, a councilman in the neighboring borough of Staten Island is already thinking of a presidential library for him.

“I believe you have a certain affection for our borough and its residents and I believe that in many ways it is shared,” councilman Joe Borelli wrote to Trump, according to the New York Post

About 57 percent of the residents in Borelli’s’ district voted for Trump in 2016.

Hmmm. A presidential library? An ex-New Yorker friend of mine scoffed: “My dear friend in Staten Island says he has a one-car garage that would be perfect!”

Some may think of other places for President Trump and his belongings. Ryker’s Island?

Peachy

As each day goes by, each hour, Donald Trump keeps making the case for impeachment. And possibly conviction.

He goes off the rails. Again. And again.

The disaster that is Donald Trump keeps giving.

It is nearly 1,000 days, America held hostage.

I thought Trump might be in bunker mode by now. That’s not his style. He’s in retaliation, tweet-in-your-face mode. What we’ve learned about Trump since the beginning of his presidency is a constant: a liar, a braggart, misleading (if not lying), angry, vengeful.

“As I learn more and more each day, I am coming to the conclusion that what is taking place is not an impeachment, it is a COUP,” Trump tweeted tonight.

George Washington calling?

Adults leaving the room are becoming a cliche when the conversation turns to some Trump aides who offered a steady course. As an anonymous author wrote in the New York Times just over a year ago: “I Am Part of the Resistance Inside the Trump Administration. The author said “many of the senior officials in his administration are working diligently from within to frustrate parts of his agenda and his worst inclinations.”

Picture school children learning about the Presidents: Yes, Donald Trump chopped down the cherry tree. He stole the cherries, eat them all himself. He bulldozed that tree, sent it to a scrap heap.

Children – we don’t know the real story of Donald Trump or how it unfolds – yet.

Trump as president: People are stressed. Every day is the longest of the year. The news cycle is old in two minutes. Frazzled. People are stuck in front of their TVs. Breaking News. Breaking News. And it is breaking news.

The weird thing with Trump is that he’s been a steady dose of overdose since the beginning. Think back to shortly after the election when the White House lied about the crowd size during the inauguration. A few weeks ago, Trump brought out his Sharpie pen and lied about a storm heading into Alabama. Between then there have been so many lies, so much misinformation, so much twisting of facts. Dog eat dog eat dog. Loyalists are showed the door and despised. Remember Tillerson? Remember Scaramucci?

“I would like you to do us a favor”

The Don—there’s been lots of Mob stories around Trump these days, too, from his parsing of the language, his talk to the Ukrainian president. Mob guys usually aren’t too blunt at least until, well, the final instruction. Trump isn’t much of a mumbler but he likes a few syllables. His sentences veer off into collisions with words that don’t make sense. Beautiful, beautiful, beautiful, no?

That whistleblower, let me have a few words with him, Trump seems to say. C’mon, send him to the Oval Office. Robert De Niro, who has played a few mobsters, calls Trump a “wannabe gangster.”

After the whistleblower disclosed his concern about the President’s talk with Ukraine president Zelensky, the political avalanche has begun, at least among Democrats. I can’t tell if Trump loves this stuff, in part, because his campaign coffers are bolstered, and he believes he’s impervious. In the meantime, Trump raises the volume of his attacks and the nonsense: accused political opponents of treason and even invoked the prospect of a civil war if he is removed from office, according to the Associated Press. 

A history of nonsense

“During the 2016 campaign, I received a phone call from an influential political journalist and author, who was soliciting my thoughts on Donald Trump,” says Peter Wehner in the Atlantic. Trump’s rise in the Republican Party was still something of a shock, and he wanted to know the things I felt he should keep in mind as he went about the task of covering Trump.

“At the top of my list: Talk to psychologists and psychiatrists about the state of Trump’s mental health, since I considered that to be the most important thing when it came to understanding him. It was Trump’s Rosetta stone.”

“Donald Trump’s disordered personality – his unhealthy patterns of thinking, functioning and behaving – has become the defining characteristic of his presidency. It manifests itself in multiple ways: his extreme narcissism; his addiction to lying about things large and small, including his finances and bullying and silencing those who could expose them: his detachment from reality, including denying things he said even when there is video evidence to the country; his affinity for conspiracy theories; his demand for total loyalty from others while showing none to others and his self-aggrandizement and petty cheating.”

Geez, that’s a long time in the Confessional…..

That loyalty thing. “I need loyalty. I expect loyalty,” Trump once said. The Republicans have been mostly in line.

Code Orange

Is this all catching up to this bizarre businessman turned politician turned instant President? Should we say Orange Head? What name hasn’t he called people?

Carl Bernstein, the Pulitzer Prize winning reporter who exposed Watergate with his partner Bob Woodward at The Washington Post, said that Trump was “unraveling.” He’s not the only one who says Trump is unraveling.

Unraveling from what? The guy has been a ball of wrapped up crazy quilt mess for a long time. More unraveling?

In the Mueller report, many of his aides described an array of anger, anger, anger surrounding Trump and things he didn’t like. Mr. Sessions are you listening? And more anger.

Loyalty vs. Real Leader

Presidential historian Doris Kearns Goodwin found that Trump lacks several traits of an effective leader, such as “humility, acknowledging errors, shouldering the blame and learning from mistakes, empathy, resilience, collaboration, connecting with people and controlling unproductive emotions.”

Er, Trump says: “I need loyalty. I expect loyalty.”

Republicans: Is this the guy you want as president?

Excuse me, I’m checking out what Kearns Goodwin said in researching Lincoln on what it takes to be a great leader.

Among the attributes:

Share Credit for Success.

Ready Willingness to Share Blame for Failure

Awareness of Own Weakness

Ability to Control Emotions.

Lincoln 100, Trump 0.

Hmm. Trump’s not there and may never be.

Denouement

Eventually, Trump’s most infamous words may be a reflection of what mobster Joey Gallo once said: “I respectfully decline to answer because I honestly believe my answer might tend to incriminate me.” – Joe Cantlupe, Health Data Buzz

Tennis, Pickleball: A Love Match?

Now that the U.S. Open is in full swing, tennis enthusiasts are abuzz about their favorite players, be it Serena or Roger.

Sometimes, you may head out to your neighborhood tennis court and approach a group of people volleying away (is that a whiffle ball?)  on what may be a makeshift mini-tennis court near a backboard. Hmm, a pickle.

These are the pickleball lovers. And they may be ready to add more courts in places where tennis may not be as welcomed as they once were.

A Maryland community outside of Washington D.C., for instance, is considering taking the step to bring pickleball to its residents by subtracting a tennis court. 

Duncan Mullis, director of recreation and parks at the Montgomery Village Foundation Inc., said leaders are weighing the idea of refurbishing one of 22 outdoor tennis courts in Montgomery Village and converting it to four courts.

A forum was held this week at Montgomery Village, a planned community of more than 40,000 residents built around 50 years ago, just outside Gaithersburg. Officials are “analyzing the data,” Mullis said on Friday.

Specifically, the plan targets one tennis court of four located at the Apple Ridge Recreation area. That one tennis court then would be remade into four pickleball courts, each of which are considerably smaller than a tennis court. In that way, it won’t interrupt the play area for the remaining tennis courts, officials say.

Residents requested the new pickleball courts, reflecting the growing popularity of the sport.

Montgomery Village’s pickleball enthusiasts have played on the outside tennis courts, but drew lines specifically for them and have brought their own nets. The drawn lines have not met specifications, Mullis said. The new plan would give the permanent courts. It might be ready in 2020, if approved.

“It is going to be several months until we have an answer on the project,” Mullis said. “Our next step is to present the data to the recreation committee.”

Question is: how will tennis players react?

“The word on the street is there is some opposition from the tennis community,” wrote a pickleball enthusiast, advocating for a “strong and voluminous show of support.”

It might not be the first time tennis players would react negatively to the idea of a new court to replace tennis courts.

In Chicago, some residents expressed  disapproval on plans to replace four tennis courts at Woodland Park with six pickleball courts.  Some of the concerns were that – because of its compact size – pickleball might be noisier. Pickleball players countered that they had to drive miles away to find some courts.

Pickleball is played on a badminton-sized court with the net lowered to 34 inches at the center. It is played with a perforated plastic ball similar to whiffle ball, wood or composite paddles, according to the The USA Pickleball Association.

Pickleball boosters say converting tennis courts — or even basketball courts – should be options to be considered for players.

Tennis players, of course, love their sport and some may not like the idea of relinquishing any courts. Some recreational officials say pickleball may a good transition for some tennis players, especially as they get older.

While the total number of tennis players in 2017 declined by 2.2 percent from the previous year to 17.68 million players, overall participation “has remained fairly consistent over the past eight years,” according to the Tennis Industry Association. — Joe Cantlupe, HealthDataBuzz.

For Budding Pharmacists, Rx: Great Need for IT Training

We’ve approached curricular experiences through the lens that informatics is going to be foundational for any type of pharmacy career,” said Dr. Beth Breeden, associate professor in the department of pharmacy practice and director of graduate studies at Lipscomb University College of Pharmacy and Health Sciences.

From my piece “All Aboard the Tech Train” for Academic Pharmacists Now  (American Association of Colleges of Pharmacy) 

https://www.aacp.org/article/all-aboard-tech-train

https://www.aacp.org/news-media/academic-pharmacy-now

Excerpts:

The wide range of academic training for pharmacy has many tributaries, especially in health IT, that touch on data issues from electronic medical records to patient safety, not to mention the increasing need to work as a clinical team with practitioners to improve healthcare outcomes.

While advocates say there is a greater need for informatics training, the movement has been slow, according to a recent progress report in the American Journal of Pharmaceutical Education (AJPE). However, there are pharmacy schools working steadily to expand student opportunities because they see HIT as part of a dynamic future in healthcare.”


In the AJPE study (co-authored by Breeden), 132 programs met inclusion criteria for review. Of these, only 47 (36 percent) included an informatics course; 64 percent were required while 47 percent were elective courses. Some 20 percent of the programs provided advanced informatics and/or introductory practice experiences, while 20 percent offered informatics residency programs. Only 17 percent listed certificate and/or graduate programs in informatics. Read the full study.- Joe Cantlupe

A Year Later: Never Again! Enough is Enough! We Call BS! ‘Survivors of a Cruel and Silent Nation’

Republished below from February 2018 on this anniversary of the horrific shooting. Our hearts  go out to families, friends, and a nation still trying to heal. The cries for hope to the end of violence still resonate.

Parkland, Fla.

Parkland has well-manicured lawns, new developments, and huge parks, with trails and tennis courts and basketball courts and ballfields. At the intersection of Coral Springs and Parkland is a horse riding academy, Malachi Acres, with a boarding stable, amidst the palms.  Town hall is beautiful, and residents talk about the sense of community. A resident recalls how there was a mini-scandal when there were some car break-ins in a neighborhood.  The reason, he said with a near smile: “The owners left their doors unlocked.” It’s that kind of place. A month ago, my wife and I left Parkland, heading to the airport after visiting relatives there. The Lyft driver told us why he moved to Parkland, this proud man from Brazil. For the schools, he said. For the schools.

Yesterday, it was about all of this, a sense of place,  the schools, and something much more profound:  passion, determination, unyielding force. Angry teen-agers with a grudge, clutching a sadness no one should have, fighting to curb gun violence, restrict the access to guns — assault weapons – and vowing, vowing, vowing to make politicians know they will be ousted from office if they don’t comply. So there is no more  terrible nonsense of gun violence that is taking lives, the “17 angels” — the 17 people –  students,  a football coach and athletic director, who were killed at Marjory Stoneman Douglas High School on Valentine’s Day. There were 14 wounded. The gunman was mentioned only in passing yesterday during the March For Our Lives rally, only in a word like horrible, but also as a pathetic reason why, why, why laws must be changed, gun laws, mental health laws, funding, you name it. All our hearts are broken, and we’ve had enough was the refrain, constant and true.

Parkland was center stage as a place, but its students were also taking the center stage  in  a rally in Washington D.C. Parkland is one piece of the gun-control puzzle. So is Chicago. So is New York. So is Miami. So is Los Angeles and everywhere where marches were held.  One bullet that fells any kid in a school, on a street. That’s what they fought against yesterday, mostly these kids, but there was plenty of support, no doubt about it, from parents, teachers, friends, the elderly.  Stop the gun violence. Stop people from having assault weapons.  Down with NRA. Thump the Trump. (ok, my term). Placard after placard. Sign after sign. The message was clear: Lawmakers and the President, if you don’t do enough you will be voted out by their supporters, damn it, when they are old enough to vote.  One student from Parkland told how she thought the privilege of the town helped draw it attention, but the fight  represents all races, all genders, all lifestyles. Those  voices at rallies across the country related personal experiences of friends, relatives, loved-ones cut down in senseless violence, in emotional, drive you to tears speeches. Eyes welling up all over.  Let’s hold those thoughts.

“We are survivors of a cruel and silent nation,” said D’Angelo McDade, 18, of Chicago at the Washington D.C. rally.  “I too, am a victim, a survivor and a victor of gun violence,” McDade said. “We are survivors not only of gun violence but of silence. I come from a place where minorities are controlled by both violence and poverty, leading us to be deterred by success. But today we say, ‘No More.’

No more, he said: violence, no more poverty, no more unjust policies and lack of resources. “You must be the change,” he told the crowd.

In 1970, after National Guard troops shot students at Kent State, we were young and demonstrated with passion and fury. We were convinced the wrongs of America would turn to rights.

We didn’t have social media. We had bull horns.

There’s something magical going  on now amidst the sadness.

These kids are articulate and their speeches are raw and practical. Blunt.  No more BS!

There are still huge bureaucratic mountains to climb, but as the protestors insisted yesterday, this is just the beginning. We’ll be hearing more of the words Ballet Box. — Joe Cantlupe

Want to Get Healthy? Location, Location, Location

First of Two Parts:


You hear the words all the time when strategizing for business. Yes, that well-worn cliché.

Location, Location, Location.

How about when it comes to personal health in the U.S.?

Well….

Location, location, location.

Do you want to live among healthy neighbors? Overland Park, KS, has the lowest share of “physically unhealthy adults.” How about not making overly costly doctor visits (that can make you sick!)….Go to Laredo, TX where patients spend the least per physician’s visit. Want to join a fitness club? Amarillo, TX has the lowest average monthly cost for a fitness-club membership. 

Those are among the findings in a WalletHub report released this week, titled 2019’s Healthiest & Unhealthiest Cities in America. Its  accompanying videos also show that “place matters” in the U.S. when it comes to being healthy – or at least what areas “prioritize residents’ well-being,” WalletHub said.

It reviewed 174 cities and what the personal finance website said were dozens – 47 —  indicators of good health. The data ranges from cost of medical care to fruit and vegetable consumption to the number of fitness clubs per capita, WalletHub said.

The top ranked? San Francisco, followed by Seattle, San Diego, Portland, Ore. and Washington DC.” Rounding out the top 10 are: New York City, Denver, Honolulu, Scottsdale, AZ, an Irvine, CA.

The lowest ranked are Brownville, Tex, Laredo, (yes, despite the low cost per doctor’s visit),  Gulfport, MS, Shreveport, LA, Huntington, West VA, Fort Smith, Ariz, Augusta, GA, Memphis, Tenn, Detroit, Montgomery, Ala, and Toledo, Ohio.

“Location matters when it comes to health,” WalletHub said in a report of its findings. “Some places promote wellness by expanding access to nutritious food and recreational facilities. Others strive to keep healthcare costs affordable for everyone or keep parks clean and well-maintained.” – Joe Cantlupe, HealthDataBuzz

Cancer: Meet T-cells.

T-Cells In Cancer Therapy

Using a patient’s own immune system is becoming a more important focus for study in cancer treatment.

Let’s talk T-cells. They are a type of white blood cells that are targeted to fight infection and diseases, particularly pathogens linked to cancer.

When a T-cell recognizes something as a threat, like a cell infected by a virus, it attacks and destroys it. The T stands for thymus, the organ in which these cells mature.

Leukemia

Such treatment is considered specifically important in the study of the treatment of leukemia because the disease “relapse occurs in 30 to 50 percent of patients and remains unacceptably high,” according to the American Society of Hematology.

Researchers say that leukemia specific T-cells that are genetically changed have proven successful in trials against leukemia.

Childhood Cancer

Children with certain cancers and other disorders of the blood and immune system also may benefit from this therapy, known as cellular immunotherapy.

CAR T-cell therapy.

T-Cells are important for CAR T-cell therapy, which directs the T-cells to cancer cells. It is a type of immunotherapy. T cells are collected from a patient, and then T cells are sent to a laboratory or a drug manufacturing facility, where CAR T cells are then infused into a patient. 

Technically, after what is known as reengineering, the T cells become known as chimeric antigen receptor CAR T cells. CAR T cells thwart the cancer cells and stay in the body after the infusion.  Early development of CAR T-cell therapies has focused largely on acute lymphoblastic leukemia, (ALL) the most common cancer in children.

“Once we infuse them back into a patient’s body through an IV, they begin multiplying and attacking tumor cells,” says Sattva Neelapu, MD, in an MD Anderson Cancer Center report at the University of Texas.  “Eventually, the hope is that CAR T-cell therapy could replace chemotherapy and stem cell transplants altogether. But first we have to show that it’s at least as effective or more effective than those therapies.

Changing Cancer Treatment

While surgery, chemotherapy and radiation were at the core of cancer treatment for years, immunotherapy that buttresses the patient’s own immune system to attack tumors as gained ground as a key element in cancer treatment.

CAR T-cell therapy has been among the most distinguished in clinical development.

“Until recently, the use of CAR T-cell therapy has been restricted to small clinical trials, largely in patients with advanced blood cancers,” said the National Cancer Institute. “But these treatments have nevertheless captured the attention of researchers and the public alike because of the remarkable responses they have produced in some patients – both children and adult – for whom all the treatments have stopped working.”

FDA approvals

In 2017, two CAR T-cell therapies were approved by the Food and

Drug Administration; one for the treatment of children with ALL, and others for adults with advanced lymphomas. That includes patients with adult B-cell, non-Hodgkin’s lymphoma.

More study ahead

Researchers caution that, “in many respects, it’s still early days for CAR T cells and other forms of ACT, including questions about whether they will ever be effective against solid tumors like breast and colorectal cancer,” the NCI says. – Joe Cantlupe, HealthDataBuzz. Contributed to hcpnow.com

References:

UPMC Hillman Cancer Center.  CAR T-Cell Therapy at UPMC Hillman Cancer Center. 2018.  Retrieved from: http://hillman.upmc.com/cancer-care/blood/treatment/car-t-cell-therapy?&gclid=Cj0KCQiAuf7fBRD7ARIsACqb8w4gYzlmUK-56EyFH4bhK062hQ7wZewhdV46dUyT1BPdeGST367tongaAo2KEALw_wcB&gclsrc=aw.ds

Dolnikov, A, Sylvie, S, et al. Stem Cell Approach to Generate Chimeric Antigen Receptor Modified Immune Effector Cells to Treat Cancer. Blood Journal. 124-2437. American Society of Hematology. 2014.  

Leukemia & Lymphom Society. 2018. Chimeric Antigen Receptor (CAR) T-Cell Therapy. 2018. Retrieved from:

https://www.lls.org/treatment/types-of-treatment/immunotherapy/chimeric-antigen-receptor-car-t-cell-therapy

Children’s Hospital of Philadelphia. 2018. Cancer Immunotherapy Program. Retrieved from: https://www.chop.edu/centers-programs/cancer-immunotherapy-program

Cynthia DeMarco. MD Anderson Cancer Center. The University of Texas. 2018. https://www.mdanderson.org/publications/cancerwise/2018/02/car-t-cell-therapy–9-things-to-know.html

National Cancer Institute. CAR T Cells: Engineering Patients’ Immune Cells to Treat Their Cancers. 2018. Retrieved from: https://www.cancer.gov/about-cancer/treatment/research/car-t-cells

A tree in China: a hope for cancer researchers

A Cancer Fighting Tree In China

Purdue University researchers are studying a tiny family of fir trees in China in hopes of finding its potential to decrease cancer-causing proteins.  It is special work because there are only a few of the trees left in the world.

The trees can grow as high as 6,000 feet and are known as Abies beshanzuensi, native to Baishanzu Shanin, the southern Zheijiang province in eastern China.

The trees have special molecules that are inhibitors of SHP2, a type of cancer-causing protein. As a result, scientists are pinpointing the protein for treating cancer, according to  Purdue University, citing a study in the Journal of the American Chemical Society.

Targeted Molecules


Targeted therapeutic action may interfere with specific proteins that help tumors grow and spread.

Unlike many of the molecules now used to target Shp2, the molecule discovered by Purdue researchers form a chemical bond with the Shp2 protein that may make it more effective. In one way, it is considered longer lasting.  It may also adhere to an FDA approved cancer drug that targets DNA for potential combination therapy. The drug Etoposide is used for multiple types of cancer.


“This is one of the most important anti-cancer targets in the pharmaceutical industry right now, for a wide variety of tumors,” said Mingji Dai, an organic chemist at Purdue University said, according to the journal of Shp2.  “A lot of companies are trying to develop drugs that work.”

Studies show that Shp2 is associated with many cancers, including breast cancer, leukemia, lung cancer, liver cancer, gastric cancer and others.  Because of that link to many cancers, Shp2 is being investigated on many fronts. “Based on the structure and function of Shp2, scientists have investigated specific mechanisms involved in cancer. Shp2 may be a potential therapeutic target,” according to the Journal of Cellular and Molecular Medicine. 

The journal adds: “In cancer, Shp2 plays different roles in various (tumors) and different microenvironments. Although great progress has been observed in studies focused on Shp2-related mechanisms, specific processes involved in such mechanisms should be further investigated.”

While targeted therapy and drug resistance are major focuses in cancer research, many molecular interactions are unknown and therefore more study is important, researchers said.

Researchers are examining the structural features of Abies beshanzuensis, particularly for its lignin, structural materials that support some plants. “Lignin are particularly important in the formation of cell walls, especially in wood and bark” and do not rot easily, experts say.

Chemists in China were initially studying the tree Abies beshanzuensis, for the possibility of treating diabetes and obesity. But the tree apparently wasn’t as effective for those conditions.


Nearly extinct


Examining the tree for its potential cancer-fighting potential has opened the door for more studies. And scientists say they don’t want to waste time in their studies. That’s because the tree is almost extinct, according to Purdue researchers. Organizations described the tree as critically endangered.


When the tree was discovered years ago, only several trees were found. By 1987, there were only three trees left in the wild, making it among the most rare – if not the rarest – conifer in the world, according to the Purdue study. New plantings have been successful, but the species is still endangered.

As a result, researchers “are racing against the extinction-clock to better understand these trees, as they could inspire powerful new ways to treat various cancer,” according to Dai, the journal said. – Joe Cantlupe, HealthDataBuzz….from publication in hcpnow.com

References:

Dexter C. Davis, Dominic G. Hoch, Li Wu, Daniel Abegg, Brandon S. Martin, Zhong-Yin Zhang, Alexander Adibekian, Mingji Dai. Total Synthesis, Biological Evaluation, and Target Identification of Rare Abies SesquiterpenoidsJournal of the American Chemical Society, 2018; 140 (50): 17465 DOI: 10.1021/jacs.8b07652

Zhang, J, Zhang, F et al. Functions of Shp2 in cancer. Journal of Cellular and Molecular Medicine. 2015. Sep; 19(9): 2-75-2083. Doi: 10.111/jcmm.12681. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4568912/

Purdue University. Science News. Researchers race against extinction to uncover tree’s cancer-fighting properties. Are we killing the cure? Retrieved from https://www.sciencedaily.com/releases/2019/01/190117115906.htm

Big Dreams of Fighting Cancer, Small Steps At a Time: Nanoparticle Research


Nanoparticles are among the tiniest in the world, but researchers have big plans for them to treat cancer.

Let’s think about what a nanoparticle is. Let’s compare it. A kiwi, which is a fruit like a pear, would actually be the size of the Earth compared to a nanoparticle, according to Sciencelearn.com. That’s how small, tiny a nanoparticle is.

Because the properties are so small, nanoparticles can easily change their structures. By doing so, they made inroads in destroying cancerous tumors, and cause less damage to healthy tissues or organs. Scientists say nanoparticles may thwart cancer cells even before they become tumors.

Targeted therapy of nanoparticles treating cancer
Researchers focus on nanoparticles for targeted drug therapy. That refers to the method in which drugs are directed to certain organs, cells, or tissues. “Nanotechnology offers the means to target chemotherapies directly and selectively to cancerous cells and neoplasms,” according to the National Cancer Institute.


For instance, the NCI said, nanoparticles can help guide surgeries or better use radiation. “All of this can add up to a decreased risk to the patient and an increased probability of survival,” the NCI said.

Nanoparticles are a focus of research into many diseases. “Research on nanotechnology cancer therapy extends beyond drug delivery into the creation of new therapeutics available only through the use of nanomaterial properties,” the NCI said.

Much research is occurring throughout the world into nanotechnology to fight cancer.

A team of researchers, affiliated with the Republic of Korea’s UNiST, recently said it introduced a “novel targeted drug delivery system that improves the pharmacological and therapeutic properties of conventional cancer treatments.” Simply put, the study involves regulating the interaction between nanoparticles and biological systems, according to a study from UNiST. 


Nanotherapy’s new technology may dramatically reduce side effects. As a result, it could show a marked improvement over existing drug therapy. “Even when the drug reaches a target such as a cancer cell, the treatment efficiency is very low and other side effects have been observed,” some of which are toxic, the study says.

According to Professor Ja-Hyoung Ryu, one of the authors of the study published in Nature Communications: “The new technology is much like the strategy where you take control of your enemies, using enemies.”


“Aside from treating cancer, our findings can also be applied to a variety of fields, such as the diagnosis and treatment of various diseases,” he adds.

Prostate cancer
Other research into nanoparticles around the world includes chemotherapy treatment research conducted at the University of Georgia. It aims to fight prostate cancer.

Researchers are using nanoparticles to deliver a certain molecule, known as IPA-3, to cancer cells. In laboratory studies involving mice, the molecule “appears to reduce the growth of prostate cancer cells,” the research shows.

Scientists at the Fred Hutchinson Research Center in Seattle, Wash. say they developed “an inexpensive way to make tumors temporarily vulnerable” using nanotechnology, says Hutch News. 

Immune-boosting drugs
The Fred Hutchinson team said it used nanoparticles “to carry immune-boosting drugs directly to solid tumors.” The immune system is the body’s defense against infection and cancer. It is made up of billions of different types of cells. T-cells are collected from patients and sent to laboratories where they are genetically engineered.

Concerns


While there is progress in nanotechnology, some experts say they are drawbacks. The concerns are “toxicity, environmental harm and organ damaged caused by nanoparticles,” says International Journal of Development and Research.  “There are some ethical issues concerned with the use of nanotechnology too.” — Joe Cantlupe. HealthDataBuzz From hcpnow.com

References:

Science Learning Hub. Retrieved from: https://www.sciencelearn.org.nz/images/2035-nanoparticle-size-comparison

Sabrina Richards. Fred Hutch. Hutch News. Nanoparticles open doors to cancer-fighting CAR T-cells. 2018. Retrieved from https://www.fredhutch.org/en/news/center-news/2018/07/liposome-nanoparticles-tumors-vulnerable-immunotherapy.html

UNiST News Center. Joo Hyeon Heo. Public Relations Team. Nature Communications. 2018. Nanoparticle Breakthrough in the Fight Against Cancer.

UnderstandingNano.com. Nanotechnology and Nanoparticles in Cancer Treatment. 2019. Retrieved from: https://www.understandingnano.com/cancer-treatment-nanotechnology.html

National Cancer Institute. Division of Cancer Treatment & Diagnosis. Treatment and Therapy. 2019. Retrieved from:  https://www.cancer.gov/sites/nano/cancer-nanotechnology/treatment

Kwatra Shubhika. International Journal of Drug Development and Research. 2017. Retrieved from: http://www.ijddr.in/drug-development/nanotechnology-and-medicine–the-upside-and-the-downside.php?aid=5003

 

Northam Mess: Physician heal thyself…(AMA weighs in…a bit)


Virginia Gov. Ralph Northam has also been a physician.

As he weighs his next move amid the swirl of controversy over his wearing blackface or KKK garb on his 1986 yearbook page at medical school, I wondered: what does the nation’s most influential association representing physicians think.

Shouldn’t the American Medical Association weigh in?

Several days after I asked the American Medical Association about what Northam did, the AMA issued a statement today to HealthDataBuzz saying it has “zero tolerance” for any kind of discrimination.

“Respecting the diversity of patients and the physicians who care for them is a fundamental value of the medical profession,” the AMA said.

The AMA did not reiterate or reflect on the tawdry Northam incident.

Last Friday it exploded. The Hill reported why: “Northam’s 1986 medical school yearbook page showed two individuals, one in blackface and the other in a Ku Klux Klan robe. The governor initially apologized for appearing in the photo, but later insisted he was not in the image. He has resisted calls for his resignation from state and national Democrats.”

‘Bigotry in Medicine’

Northam the politician is in trouble. But his conduct in medical school not only has “stirred a national political furor,” as the Associated Press reported, but it also “reopened the long history of bigotry in American medicine.”

“The revelations about Northam gave many African-Americans a new reason to be distrustful of doctors,” AP said.

In its statement, the AMA did not mention Northam or the particulars of the controversy. The AMA said it is “committed to improving health outcomes for all patients, confronting disparities in health care, and increasing the ranks of minority physicians so the workforce accurately represents the diversity of America’s patients.”

The AMA wasn’t asked that question. But it took the occasion of the Northam outrage to say there is a way to go that there may be enough minority physicians to reflect the face of America as it is today.

According to a Deloitte report, for instance, 68.2% of physicians and surgeons in the U.S. in 2016 were white, “making that the most common race or ethnicity in the occupation.” About 5.7 % are black — although African-Americans comprise 11.9% of the workforce, it said.

There is a way to go before racism is erased.

In July 2008, the AMA “issue a formal apology for discriminating against black physicians well into the 1960s, with damaging effects that persist today,” MedPage Today reported at the time.

The AMA acknowledged “its past history of racial inequality toward African-American physicians,” it was reported.

Joe Cantlupe, Health Data Buzz